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ONLINE COVER Waves of IgA Regulate the Intestinal Microbiota. This month’s cover depicts the dynamic interplay between immunoglobulin A (IgA) and the commensal microbiota in the intestinal lumen. Penny and Domingues et al. report that secretory IgA exhibits daily rhythms in its release from lamina propria plasma cells into the intestinal tract, which are controlled by signals provided by food and the circadian clock. These “waves” of IgA regulate the daily oscillations in the relative abundance of commensal gut microbes to help maintain gut homeostasis.

Credit: Helena Pinheiro

Science Immunology

  • Volume 7|
  • Issue 75|
  • Sep 2022

ONLINE COVER Waves of IgA Regulate the Intestinal Microbiota. This month’s cover depicts the dynamic interplay between immunoglobulin A (IgA) and the commensal microbiota in the intestinal lumen. Penny and Domingues et al. report that secretory IgA exhibits daily rhythms in its release from lamina propria plasma cells into the intestinal tract, which are controlled by signals provided by food and the circadian clock. These “waves” of IgA regulate the daily oscillations in the relative abundance of commensal gut microbes to help maintain gut homeostasis.

Credit: Helena Pinheiro

Research Articles

    BY
    • Dorothea Dörr
    • Benedikt Obermayer
    • January Mikolaj Weiner
    • Karin Zimmermann
    • Chiara Anania
    • Lisa Katharina Wagner
    • Ekaterini Maria Lyras
    • Valeriia Sapozhnikova
    • David Lara-Astiaso
    • Felipe Prósper
    • Roland Lang
    • Darío G. Lupiáñez
    • Dieter Beule
    • Uta E. Höpken
    • Achim Leutz
    • Alexander Mildner
  • NO ACCESS
The molecular network of surfactant lipid metabolism in alveolar macrophages is orchestrated by the transcription factor C/EBPβ.
    BY
    • Hugo A. Penny
    • Rita G. Domingues
    • Maria Z. Krauss
    • Felipe Melo-Gonzalez
    • Melissa A. E. Lawson
    • Suzanna Dickson
    • James Parkinson
    • Madeleine Hurry
    • Catherine Purse
    • Emna Jegham
    • Cristina Godinho-Silva
    • Miguel Rendas
    • Henrique Veiga-Fernandes
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    • Richard K. Grencis
    • Kai-Michael Toellner
    • Ari Waisman
    • Jonathan R. Swann
    • Julie E. Gibbs
    • Matthew R. Hepworth
  • NO ACCESS
Diurnal rhythms in intestinal IgA act to cross-regulate oscillations in the abundance of commensal microbes to foster mutualism.
    BY
    • Tianli Xiao
    • P. Kent Langston
    • Andrés R. Muñoz-Rojas
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  • NO ACCESS
Visceral adipose tissue Tregs turn up cell-intrinsic circadian rhythms to promote cellular fitness and regulate diurnal lipolysis.
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    • Mehdi Benamar
    • Klaus Schmitz-Abe
    • Varsha Poondi-Krishnan
    • Qian Chen
    • Bat-Erdene Jugder
    • Benoit Fatou
    • Jason Fong
    • Yuelin Zhong
    • Stuti Mehta
    • Altantsetseg Buyanbat
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    • Safa Baris
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    • Sevgi Keles
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  • NO ACCESS
Stk4 combines with NF-κB and Foxp3 in a TCR-regulated trimolecular complex to mediate Treg cell activation and homeostasis.
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  • Open Access
IMM-BCP-01 is efficacious against Omicron, induces dissociation of Spike protein, and triggers a potent effector response.
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  • NO ACCESS
The microbial metabolite trimethylamine N-oxide (TMAO) relieves immunosuppression in the tumor microenvironment of pancreatic cancer.
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    • David Bomze
    • Christa Lichtensteiger
    • Vincent Walter
    • Rebekka Niederer
    • Omar Hasan Ali
    • Nina Wyss
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    • Lena Katharina Freudenmann
    • Ana Marcu
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    • Stefan Diem
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    • Oltin Tiberiu Pop
    • Ann-Kristin Jochum
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  • NO ACCESS
We share a method called DITAS for the identification of tumor antigens in immune checkpoint blockade-treated cancer patients.
    BY
    • Sandra Zehentmeier
    • Vivian Y. Lim
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    • Julia Fossati
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  • NO ACCESS
Increased LTï¢R signaling in mesenchymal stem cells reduces IL-7 production and causes lymphopenia in WHIM syndrome.
    BY
    • Colin Sparano
    • Darío Solís-Sayago
    • Anjali Vijaykumar
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  • NO ACCESS
Characterization of murine group 1 ILC development reveals a layered ontogeny influenced by tissue and age.
    BY
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  • Open Access
BA.1 infection after BNT162b2 vaccination drives cross-variant neutralization and memory B cell formation against conserved epitopes.
    BY
    • David A. Christian
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    • Lindsey A. Shallberg
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    • Tony E. Smith
    • Mosana Abraha
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    • Gordon Ruthel
    • Joseph T. Clark
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    • Selamawit Gossa
    • Dorian B. McGavern
    • Ross M. Kedl
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  • NO ACCESS
cDC1s are not required for T cell priming but coordinate immune responses in the omentum to generate protective T cell responses.
    BY
    • Paôline Laurent
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    • André F. Rendeiro
    • Benjamin E. Nilsson-Payant
    • Lucia Carrau
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    • Lionel B. Ivashkiv
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  • Open Access
The priming of macrophages by SARS-CoV-2-infected pDCs provokes an inflammatory response to microbial components in patient lungs.

Editors’ Choice

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    • Jonathan S. Maltzman
  • NO ACCESS
Adipocyte derived SPARC induces pro-inflammatory changes to macrophages, leading to aging that can be reduced by caloric restriction.
    BY
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  • NO ACCESS
Cryo-EM analysis of a complete TCR complex with bound peptide-MHC provides evidence against ligand-induced allosteric conformational changes.

Reports

    BY
    • Cassandra R. Harapas
    • Kim S. Robinson
    • Kenneth Lay
    • Jasmine Wong
    • Ricardo Moreno Traspas
    • Nasrin Nabavizadeh
    • Annick Rass-Rothschild
    • Bertrand Boisson
    • Scott B. Drutman
    • Pawat Laohamonthonkul
    • Devon Bonner
    • Jingwei Rachel Xiong
    • Mark D. Gorrell
    • Sophia Davidson
    • Chien-Hsiung Yu
    • Mark D. Fleming
    • Jonas Gudera
    • Jerry Stein
    • Miriam Ben-Harosh
    • Emily Groopman
    • Akiko Shimamura
    • Hannah Tamary
    • Hülya Kayserili
    • Nevin Hatipoğlu
    • Jean-Laurent Casanova
    • Jonathan A. Bernstein
    • Franklin L. Zhong
    • Seth L. Masters
    • Bruno Reversade
  • Free
Loss of DPP9 activity in humans, mice and zebrafish results in pathogenic NLRP1 overactivation.
    BY
    • Anna Z. Mykytyn
    • Melanie Rissmann
    • Adinda Kok
    • Miruna E. Rosu
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    • Tim I. Breugem
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    • Felicity Chandler
    • Theo Bestebroer
    • Maurice de Wit
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    • Richard Molenkamp
    • Bas B. Oude Munnink
    • Rory D. de Vries
    • Corine GeurtsvanKessel
    • Derek J. Smith
    • Marion P. G. Koopmans
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    • Ron A. M. Fouchier
    • Bart L. Haagmans
  • Open Access
Antigenic evolution by SARS-CoV-2 can be monitored by antigenic cartography, informing future coronavirus vaccine strain selections.

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