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COVER Like many viruses, SARS-CoV-2 deploys a molecular arsenal to neutralize the host's immune response. Many of the viral proteins shown here suppress steps in the body’s interferon response, for example (the arrangement and colors of the proteins indicate which genes encode them). An interactive version of the news feature can be found online at https://scim.ag/ViralArsenal. See page 128.

Illustration: V. Altounian, C. Bickel, K. Franklin/Science; Data: see https://scim.ag/ViralArsenal

Science

  • Volume 378|
  • Issue 6616|
  • 14 Oct 2022

COVER Like many viruses, SARS-CoV-2 deploys a molecular arsenal to neutralize the host's immune response. Many of the viral proteins shown here suppress steps in the body’s interferon response, for example (the arrangement and colors of the proteins indicate which genes encode them). An interactive version of the news feature can be found online at https://scim.ag/ViralArsenal. See page 128.

Illustration: V. Altounian, C. Bickel, K. Franklin/Science; Data: see https://scim.ag/ViralArsenal

Editorial

  • BY
    • Stephen Herzog
  • : 115
  • FULL ACCESS
  • BY
    • H. Holden Thorp
  • : 117
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News

In Brief
  • : 118-119
In Depth
  • BY
    • Dyna Rochmyaningsih
  • : 120-121
Five foreign scientists banned after critical op-ed; animal population estimates shelved
  • BY
    • Elizabeth Pennisi
  • : 121-122
Mutations helped animals adapt to extreme temperatures, low oxygen
Rocky meteor suggests distant cloud of comets also contains asteroids
  • BY
    • Jacklin Kwan
  • : 124
Costly adaptations help stave off effects of wildfires, storms, and hot weather
  • BY
    • Daniel Clery
    • Robert F. Service
  • : 125
Trio of researchers pioneered “click chemistry” to design drugs and industrial materials
Authors were dropped from broader Lancet review
Feature
  • BY
    • Mitch Leslie
  • : 128-131
SARS-CoV-2 wields versatile proteins to foil our immune system’s counterattack

Insights

Perspectives
  • BY
    • Ning Yan
  • : 132-133
  • NO ACCESS
Integrating oxidation and bioconversion provides a solution to recycle mixed plastics
  • BY
    • Chuanbo Gao
    • Osamu Terasaki
  • : 133-134
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Charges on a metal nanoparticle are measured with precision by electron holography
  • BY
    • Megan Sykes
  • : 135-136
  • NO ACCESS
Recent advances raise hope for a promising solution to the transplant organ shortage
  • BY
    • Robert E. Sharwood
  • : 137-138
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Analysis of Rubisco evolution could inform how to engineer a better enzyme
  • BY
    • Ting Ma
    • Jodie L. Lutkenhaus
  • : 138-139
  • NO ACCESS
A fuel cell gains more power from ion-conducting, porous covalent organic frameworks
  • BY
    • Timo van Kerkoerle
    • Martijn A. Cloos
  • : 139-140
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A noninvasive imaging technique measures neuronal activity at a millisecond time scale
Policy Forum
  • BY
    • Maya Sabatello
    • Daphne O. Martschenko
    • Mildred K. Cho
    • Kyle B. Brothers
  • : 141-143
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Data sharing must be accompanied by responsibility sharing
Books et al.
  • BY
    • James M. Jones
  • : 144
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A pair of authors urge readers to confront society’s shortcomings and build a better future
  • BY
    • D. W. Stahle
  • : 145
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Reverence for old trees sparked early forest conservation efforts, even as ancient woodlands were cut with impunity
Letters
  • BY
    • Juan L. Celis-Diez
    • Nélida Pohl
  • : 147
  • NO ACCESS
  • BY
    • Pablo J. Donoso
    • Daniel P. Soto
    • Celso Navarro
    • Yasna Rojas
  • : 147-148
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  • BY
    • Mingli Lin
    • Samuel T. Turvey
    • Mingming Liu
    • Heidi Ma
    • Songhai Li
  • : 148
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Research

Research Highlights
  • BY
    • Michael A. Funk
    • Peter Stern
    • Brent Grocholski
    • L. Bryan Ray
    • Pamela J. Hines
    • Marc S. Lavine
    • Caitlin Czajka
    • Wei Wong
    • Stella M. Hurtley
    • Gemma Alderton
    • Phil Szuromi
    • Claire Olingy
  • : 149-150
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Highlights from the Science family of journals
  • BY
    • Di Jiang
    • Brad Wible
    • Mattia Maroso
    • Priscilla N. Kelly
    • Michael A. Funk
    • Ekeoma Uzogara
    • Jelena Stajic
  • : 150-151
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Editors’ selections from the current scientific literature
Research Articles
  • BY
    • Qiyao Chai
    • Shanshan Yu
    • Yanzhao Zhong
    • Zhe Lu
    • Changgen Qiu
    • Yang Yu
    • Xinwen Zhang
    • Yong Zhang
    • Zehui Lei
    • Lihua Qiang
    • Bing-Xi Li
    • Yu Pang
    • Xiao-Bo Qiu
    • Jing Wang
    • Cui Hua Liu
  • NO ACCESS
A mycobacterial phosphatase binds ubiquitin to alter host membrane phospholipids to subvert gasdermin D–mediated cell death.
  • BY
    • Ying Yin
    • Feng Zhang
    • Shasha Feng
    • Kevin John Butay
    • Mario J. Borgnia
    • Wonpil Im
    • Seok-Yong Lee
  • NO ACCESS
An open-state structure reveals how cold sensing channels can be activated by chemicals.
  • BY
    • Luca Schulz
    • Zhijun Guo
    • Jan Zarzycki
    • Wieland Steinchen
    • Jan M. Schuller
    • Thomas Heimerl
    • Simone Prinz
    • Oliver Mueller-Cajar
    • Tobias J. Erb
    • Georg K. A. Hochberg
  • : 155-160
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Ancestral sequence reconstruction reveals how recruiting a new subunit primes form I Rubiscos for rising atmospheric oxygen.
  • BY
    • Phan Tan Toi
    • Hyun Jae Jang
    • Kyeongseon Min
    • Sung-Phil Kim
    • Seung-Kyun Lee
    • Jongho Lee
    • Jeehyun Kwag
    • Jang-Yeon Park
  • : 160-168
  • NO ACCESS
A noninvasive neuroimaging method allows direct mapping of neuronal action potentials in a living mouse brain with high resolution.
  • BY
    • Yufeng Zhang
    • Qian Lv
    • Haidong Wang
    • Shuaiyi Zhao
    • Qihua Xiong
    • Ruitao Lv
    • Xing Zhang
  • : 169-175
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A monolayer heterostructure rectifier was developed to obtain simultaneous electrical and thermal rectification.
  • BY
    • Mari Ogawa-Ohnishi
    • Tomohide Yamashita
    • Mitsuru Kakita
    • Takuya Nakayama
    • Yuri Ohkubo
    • Yoko Hayashi
    • Yasuko Yamashita
    • Taizo Nomura
    • Saki Noda
    • Hidefumi Shinohara
    • Yoshikatsu Matsubayashi
  • : 175-180
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A ligand deprivation–dependent activation system helps plants tune stress responses near damaged sites.
  • BY
    • Qingnuan Zhang
    • Shuda Dong
    • Pengpeng Shao
    • Yuhao Zhu
    • Zhenjie Mu
    • Dafei Sheng
    • Teng Zhang
    • Xin Jiang
    • Ruiwen Shao
    • Zhixin Ren
    • Jing Xie
    • Xiao Feng
    • Bo Wang
  • : 181-186
  • NO ACCESS
Adding a sulfonated ionic covalent organic framework into the Nafion ionomer improves gas transport to the catalyst layer.
  • BY
    • Brian D. Reed
    • Michael J. Meyer
    • Valentin Abramzon
    • Omer Ad, [email protected]
    • Omer Ad
    • Pat Adcock
    • Faisal R. Ahmad
    • Gün Alppay
    • James A. Ball
    • James Beach
    • Dominique Belhachemi
    • Anthony Bellofiore
    • Michael Bellos
    • Juan Felipe Beltrán
    • Andrew Betts
    • Mohammad Wadud Bhuiya
    • Kristin Blacklock
    • Robert Boer
    • David Boisvert
    • Norman D. Brault
    • Aaron Buxbaum
    • Steve Caprio
    • Changhoon Choi
    • Thomas D. Christian
    • Robert Clancy
    • Joseph Clark
    • Thomas Connolly
    • Kathren Fink Croce
    • Richard Cullen
    • Mel Davey
    • Jack Davidson
    • Mohamed M. Elshenawy
    • Michael Ferrigno
    • Daniel Frier
    • Saketh Gudipati
    • Stephanie Hamill
    • Zhaoyu He
    • Sharath Hosali
    • Haidong Huang
    • Le Huang
    • Ali Kabiri
    • Gennadiy Kriger
    • Brittany Lathrop
    • An Li
    • Peter Lim
    • Stephen Liu
    • Feixiang Luo
    • Caixia Lv
    • Xiaoxiao Ma
    • Evan McCormack
    • Michele Millham
    • Roger Nani
    • Manjula Pandey
    • John Parillo
    • Gayatri Patel
    • Douglas H. Pike
    • Kyle Preston
    • Adeline Pichard-Kostuch
    • Kyle Rearick
    • Todd Rearick
    • Marco Ribezzi-Crivellari
    • Gerard Schmid
    • Jonathan Schultz
    • Xinghua Shi
    • Badri Singh
    • Nikita Srivastava
    • Shannon F. Stewman
    • TR [email protected]
    • T. R. Thurston
    • Philip Trioli
    • Jennifer Tullman
    • Xin Wang
    • Yen-Chih Wang
    • Eric A. G. Webster
    • Zhizhuo Zhang
    • Jorge Zuniga
    • Smita S. Patel
    • Andrew D. Griffiths
    • Antoine M. van Oijen
    • Michael McKenna
    • Matthew D. Dyer
    • Jonathan M. Rothberg
  • : 186-192
  • NO ACCESS
Single-molecule peptide sequences are determined by N-terminal amino acid recognizers.
  • BY
    • Nabora S. Reyes
    • Maria Krasilnikov
    • Nancy C. Allen
    • Jin Young Lee
    • Ben Hyams
    • Minqi Zhou
    • Supriya Ravishankar
    • Monica Cassandras
    • Chaoqun Wang
    • Imran Khan
    • Peri Matatia
    • Yoshikazu Johmura
    • Ari Molofsky
    • Michael Matthay
    • Makoto Nakanishi
    • Dean Sheppard
    • Judith Campisi
    • Tien Peng
  • : 192-201
  • NO ACCESS
Mouse lung cells expressing a marker of senescence appear to promote regeneration after injury.
Reviews
  • BY
    • Vijay G. Sankaran
    • Jonathan S. Weissman
    • Leonard I. Zon
  • NO ACCESS
A review discusses how cellular barcoding can improve our understanding of cell dynamics in human health and disease.
Reports
  • BY
    • Ryotaro Aso
    • Hajime Hojo
    • Yoshio Takahashi
    • Tetsuya Akashi
    • Yoshihiro Midoh
    • Fumiaki Ichihashi
    • Hiroshi Nakajima
    • Takehiro Tamaoka
    • Kunio Yubuta
    • Hiroshi Nakanishi
    • Hisahiro Einaga
    • Toshiaki Tanigaki
    • Hiroyuki Shinada
    • Yasukazu Murakami
  • : 202-206
  • NO ACCESS
Phase-shift analysis on the vacuum-protruding region of nanoparticles visualized slight positive and negative charging.
  • BY
    • Kevin P. Sullivan
    • Allison Z. Werner
    • Kelsey J. Ramirez
    • Lucas D. Ellis
    • Jeremy R. Bussard
    • Brenna A. Black
    • David G. Brandner
    • Felicia Bratti
    • Bonnie L. Buss
    • Xueming Dong
    • Stefan J. Haugen
    • Morgan A. Ingraham
    • Mikhail O. Konev
    • William E. Michener
    • Joel Miscall
    • Isabel Pardo
    • Sean P. Woodworth
    • Adam M. Guss
    • Yuriy Román-Leshkov
    • Shannon S. Stahl
    • Gregg T. Beckham
  • : 207-211
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Autoxidation and biological funneling converts mixed plastics to a single product.
  • BY
    • Adrian K. Rylski
    • Henry L. Cater
    • Keldy S. Mason
    • Marshall J. Allen
    • Anthony J. Arrowood
    • Benny D. Freeman
    • Gabriel E. Sanoja
    • Zachariah A. Page
  • : 211-215
  • NO ACCESS
Spatially synthesizing stiff and elastic domains from a single monomer forms robust synthetic plastics.

Careers

Working Life
  • BY
    • Arijit Mukherjee
  • : 218
  • Free

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