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Science Signaling

  • Volume 16
  • Issue 771
  • 07 Feb 2023
Go to Science Signaling
Go to Science Signaling

ONLINE COVER This week, Gamage et al. show that the deletion of a single amino acid (Glu296) reverses the pathophysiological effects of the disease-associated R304W mutation of the ER Ca2+ sensor STIM1 by restoring the intramolecular contacts required for the inactive conformation. The image shows μCT scans of cortical (top row) and trabecular (bottom row) bone in a wild-type mouse (left column), a mouse expressing the R304W mutant (center column), and a mouse expressing STIM1 with both the R304W mutation and Glu296 deletion (right column).

Credit: Liebert Parreiras Nogueira/Institute of Clinical Dentistry, University of Oslo

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Science Signaling is a weekly, online journal for the life sciences. We publish studies that uncover basic mechanisms underlying biological processes in all organisms. We are particularly interested in studies that provide new insights into physiology, delineate mechanisms that cause disease, identify potential therapeutic targets and strategies, and characterize the effects of drugs.

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