ONLINE COVER This week, Slabber et al. demonstrate that the ubiquitin ligase Uhrf2 protects the mouse liver during regeneration by suppressing cholesterol biosynthesis. In the absence of Uhrf2, regenerating livers accumulated cholesterol and bile acids and showed widespread necrosis. The images are H&E-stained sections of regenerating livers from a control mouse at the top and a Uhrf2-deficient mouse at the bottom. Pale regions indicate areas of necrosis.