Science Signaling
- Volume 15
- Issue 754
- 04 Oct 2022
ONLINE COVER This week, Kong et al. show that the kinase PLK1 promotes the growth of some lung cancers by stimulating the expression of RET, which encodes a receptor kinase that increases the activity of a tumor growth–promoting pathway. The image shows stained lung tissues from mouse models of KRAS-mutant lung adenocarcinoma.
Credit: Kong et al./Science SignalingResearch ArticlesBy
- Xinying Zhou
- Zelin Zhang
- et al.
Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection
Research ArticlesBy
- Yifan Kong
- Derek B. Allison
- et al.
The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET
Editors' ChoiceBy
- Amy E. Baek
Charting metastasis
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Science Signaling is a weekly, online journal for the life sciences. We publish studies that uncover basic mechanisms underlying biological processes in all organisms. We are particularly interested in studies that provide new insights into physiology, delineate mechanisms that cause disease, identify potential therapeutic targets and strategies, and characterize the effects of drugs.
mission & scopeEditors’ Choice
4 Oct 2022
Charting metastasis
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