
Science Signaling
- Volume 16
- Issue 787
- 30 May 2023

ONLINE COVER This week, Slabber et al. demonstrate that the ubiquitin ligase Uhrf2 protects the mouse liver during regeneration by suppressing cholesterol biosynthesis. In the absence of Uhrf2, regenerating livers accumulated cholesterol and bile acids and showed widespread necrosis. The images are H&E-stained sections of regenerating livers from a control mouse at the top and a Uhrf2-deficient mouse at the bottom. Pale regions indicate areas of necrosis.
Credit: Slabber et al./Science Signaling- Coenraad Frederik Slabber
- Marc Bachofner
- et al.
The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration
- Vincent Quoc-Huy Trinh
- Ting-Fang Lee
- et al.
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
- Katharina Schönberger
- Jan S. Tchorz
Hepatic stellate cells: From bad reputation to mediators of liver homeostasis
- Wei Wong
Switching off the bat signal
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Science Signaling is a weekly, online journal for the life sciences. We publish studies that uncover basic mechanisms underlying biological processes in all organisms. We are particularly interested in studies that provide new insights into physiology, delineate mechanisms that cause disease, identify potential therapeutic targets and strategies, and characterize the effects of drugs.
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