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Perspective
Molecular Biology

Activating translation with phase separation

Ribonucleoprotein granules allow activation of translation to complete mouse spermatogenesis
Science
11 Aug 2022
Vol 377, Issue 6607
pp. 712-713

Abstract

Phase separation allows cellular organization through the coordination of biochemical reactions into membraneless biomolecular condensates (1). Studies have focused on the biophysical properties and dynamics of biomolecular condensates. Now, a key issue to address is the biological functions of these condensates: Can phase separation induce specific functions and, if so, how (2, 3)? In the cytoplasm, messenger RNAs (mRNAs) and RNA binding proteins assemble into biomolecular condensates called ribonucleoprotein (RNP) granules that are intimately linked to RNA biology. RNP granules have been associated with mRNA storage and translational repression. On page 727 of this issue, Kang et al. (4) report translational activation as a previously unknown function of biomolecular condensates, showing that phase separation of the RNA binding protein FXR1 (fragile X mental retardation syndrome–related protein 1) is required for completion of spermatogenesis in mice.

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References and Notes

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Science
Volume 377 | Issue 6607
12 August 2022

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Published in print: 12 August 2022

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Acknowledgments

The Simonelig laboratory is supported by grants from Agence Nationale de la Recherche (ANR-17-CE12-0011-01, ANR-19-CE12-0031, and ANR-21-CE12-0035-01), Fondation pour la Recherche Médicale, Fondation pour la Recherche sur le Cancer, and the Labex EpiGenMed.

Authors

Affiliations

Anne Ramat
Institute of Human Genetics, Université Montpellier, CNRS, Montpellier, France.
Martine Simonelig [email protected]
Institute of Human Genetics, Université Montpellier, CNRS, Montpellier, France.

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