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Abstract

Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

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References

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Information & Authors

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Published In

Science
Volume 220 | Issue 4600
27 May 1983

Submission history

Received: 8 November 1982
Published in print: 27 May 1983

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Soo Y. Ko
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
Albert W. M. Lee
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
Satoru Masamune
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
Lawrence A. Reed, III
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
K. Barry Sharpless
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139
Frederick J. Walker
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139

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